- Inflammation Rewires the Brain
- The Role of Psychological and Environmental Triggers
- Treating the Phantom Itch
With phantom itch, You dont see the patches or the plaques, but they'll still be persistently itchy, says Shira Y. Wieder, MD, a board-certified dermatologist at Montefiore Einstein and an assistant professor of dermatology at the Albert Einstein College of Medicine in New York City. There's nothing there that you can see with the eye, but there's clearly something going on under the surface.
Sometimes the itchy sensation even feels like its moving around. Thats due to the overactive nerve cells under the surface of the skin, which keep firing off itch signals even after the inflammation you can see has quieted down, explains Aderonke Obayomi, MD, MPH, a board-certified dermatologist and assistant professor at Mount Sinai in New York City.
Just because your symptoms are invisible, though, doesnt mean they're not treatable.
How Chronic Inflammation Rewires the Brain
Your immune system and nervous system are in constant communication with each other. But with atopic dermatitis, your immune system sends out the wrong messages.
Think of a smoke alarm thats been turned up too high, Obayomi says. It goes off from a little steam, not just an actual fire. In eczema, the itch nerves get rewired to overreact, and the spinal cord and brain amplify those signals, too.
Psychological and Environmental Triggers
You might catch yourself scratching without even noticing you started, maybe while zoning out during a work meeting or while winding down at night, Obayomi says. The more you scratch, the more ingrained the habit becomes. The brain starts pairing certain moments, like getting into bed, with scratching, until it becomes almost automatic, she says.
Treating the Phantom Itch
- Keeping fingernails short
- Covering the itchy area with comfortable clothing, bandages, or cool compresses
- Wearing loose-fitting clothing made from soft, breathable fabrics
- Taking lukewarm rather than hot showers
- Keeping your bedroom cool at night
- Consistently moisturizing with a thick, fragrance-free cream to protect the skin barrier
- Running a humidifier, especially during the winter when indoor heat dries the air
You might also need treatment for the inflammation simmering beneath your skin. The most important move is to treat the eczema itself, because chasing the itch on its own wont get you far, Obayomi says. Medications might include systemic drugs such as oral immunosuppressants, biologics, or JAK inhibitors.
The interconnected nature of inflammatory and neuropathic itchiness has also brought about new treatment options. Sometimes the treatments aimed at tamping down atopic dermatitis can also soothe a phantom itch, even if no other symptoms are present.
Remember that even though you may not see any signs of atopic dermatitis, your itchiness is valid. Phantom itch is real, says Obayomi. It is not in your head, even when your skin looks perfectly clear. That validation matters for everyone, and it matters even more for patients of color, where a flare can be harder to spot and easier to wave off.
Talk to a trusted healthcare provider sooner rather than later. If the itch is running your life, thats a good reason to see a dermatologist who treats a lot of eczema and wont stop at It looks fine, Obayomi says.
The Takeaway
- Atopic dermatitis can cause a phantom itch, even when there are no visible signs of eczema on the skin. This is due to chronic inflammation that makes nerves under the skin extra sensitive.
- The itch-scratch cycle can further sensitize nerves, exacerbating the itch. Scratching can be a learned habit or stress response, and itchiness can worsen due to environmental factors like clothing choices and weather changes.
- Moisturizing, keeping fingernails short, and keeping your hands busy may help, but you may also benefit from asking your dermatologist about medication that can tame atopic dermatitis-related inflammation.
- What Is Neuropathic Itch? Columbia Doctors. April 1, 2024.
- Nelson S. The Complex Science Behind Itch in Atopic Dermatitis. National Eczema Association. July 30, 2021.
- Meixiong J et al. Neuropathic Itch. Cells. October 9, 2020.
- Charifa A et al. Lichen Simplex Chronicus. StatPearls. August 7, 2023.
- Eczema (Atopic Dermatitis) Overview. American Academy of Allergy Asthma & Immunology. June 18, 2026.
- Atopic Dermatitis: A Guide for Your Family. Boston Childrens Hospital. March 22, 2023.
- Ways to Relieve Itch from Eczema. National Eczema Foundation. March 4, 2025.
- Dermatitis (Eczema) in Older Adults. American Academy of Allergy, Asthma, & Immunology.
Sanober Pezad Doctor, MD
Medical Reviewer
Dr. Sanober Pezad Doctor is a double board-certified dermatologist and internationally recognized leader in integrative and holistic dermatology. She is an anti-aging and regenerat...
Sarah Klein
Author
Sarah Klein is a Boston-based health journalist with more than 15 years experience in lifestyle media. She has held staff positions at Livestrong, Health, Prevention, and Huffingto...