Devil Fruits are the cornerstone of the power system of One Piece. Introduced in the very beginning of the story, these Devil Fruits were shown to hold mystical powers that they grant to their eaters, and in exchange, take their ability to swim. Devil Fruits offer an array of abilities, and there is no power that one can imagine that they cannot grant. This is simply down to the fact that Devil Fruits actually stem from the imagination of humans, and exist as an alternate kind of evolution, as was confirmed by Vegapunk himself.
While all Devil Fruits are strong in their own ways, there are some that can be considered to be too powerful. In fact, there are quite a lot of Devil Fruits that can actually kill anyone in a single shot, and these are believed to be on a completely different level of power.
Mero Mero no Mi
- Type: Paramecia
- User: Boa Hancock
The Mero Mero no Mi is an incredible Devil Fruit utilized by Boa Hancock, the Pirate Empress. This Devil Fruit allows Hancock to petrify anyone who stands in her path, especially those who are attracted to her. That said, this Devil Fruit isn't limited to attraction, as it can even petrify inanimate objects.
The Mero Mero no Mi simply needs a single touch of the user to petrify someone. If hit with Mero Mero Mellow, then the user can turn their target into stone immediately. Only Hancock can undo this process of petrification, and this power is so strong that even Teach, a Yonko of the Sea, feared it and couldn't undo it.
Magu Magu no Mi
- Type: Logia
- User: Sakazuki
The Magu Magu no Mi is a Logia-type Devil Fruit eaten by the new Fleet Admiral Sakazuki. This fruit is one of the most overpowered ones and is believed to hold offensive power of the highest order. This Devil Fruit allows him to turn into, as well as create and manipulate magma at will. As such, this Devil Fruit can simply inundate anyone in magma and kill them in a single shot. In the battle against Ace, Akainu showed that he is strong enough to kill in one clean hit.
Goro Goro no Mi
- Type: Logia
- User: Enel
Goro Goro no Mi is one of the few Devil Fruits known to be invincible. This is an incredible power belonging to the Logia class that was eaten by Enel at some point. Of course, due to being a Logia ability, the user can turn into, as well as produce and manipulate lightning at will.
The Goro Goro no Mi possesses enough power to destroy an entire island without even Awakening the fruit. This fruit can easily kill the vast majority of the characters in One Piece in a single shot, which is what makes it a truly dangerous ability.
Doku Doku no Mi
- Type: Paramecia
- User: Magellan
Eaten by the former Warden of Impel Down, Magellan, the Doku Doku no Mi is a very powerful Devil Fruit that allows him to manipulate poisons, and this Devil Fruit is incredibly powerful, as it gives him control over millions of types of toxins that he can easily control however he wants.
This fruit stands as an incredible ability and one that is fatal. It could have killed Luffy in a single shot back in the Impel Down Arc, and it could even have taken down the entire Blackbeard crew in a single shot had they not received an antidote.
Ope Ope no Mi
- Type: Paramecia
- User: Trafalgar Law, Unknown Doctor From The Void Century
Utilized by the Surgeon of Death, Trafalgar Law, the Ope Ope no Mi is one of the most overpowered abilities in the world of One Piece. This fruit gives Law the ability to operate on anyone inside the ROOMs that he can create with the power it grants.
Essentially, anything inside his ROOM is like a patient on his operating table, and he can even manipulate the entire terrain as he wants. Law possesses tremendous strength inside his ROOMs, and now that he has Awakened his Devil Fruit, it can certainly kill in one shot, using the powerful abilities such as Puncture Wille.
Gasu Gasu no Mi
- Type: Logia
- User: Caesar Clown
The Gasu Gasu no Mi is a powerful Logia that was introduced to the fans in the Punk Hazard Arc, through its user, Caesar Clown. This ability allowed Caesar to turn into, as well as produce and manipulate gases at will.
Caesar had the ability to remove oxygen from small spaces. Under a better user, this fruit can be deadly. It can certainly kill anyone in one shot using oxygen removal, and that alone makes it one of the most dangerous powers to exist.
Soru Soru no Mi
- Type: Paramecia
- User: Former Yonko Big Mom
Eaten by the former Emperor of the Sea, Big Mom, the Soru Soru no Mi is one of the most dangerous abilities that Oda has introduced in One Piece. This Devil Fruit allows the user to manipulate souls however they want. It is an incredible ability using which the user can rip out the soul, or in some cases, the partial lifespan of an enemy in a single shot.
It can kill those who don't have much of their life left. However, depending on Big Mom, some can survive this ability. Of course, this ability only works if the target fears the user. However, given that Big Mom wields this ability, the vast majority of people in the One Piece world do actually fear her. Furthermore, this Devil Fruit also possesses other abilities that give Big Mom enough power to kill nearly anyone in one shot.
Gura Gura no Mi
- Type: Paramecia
- User: Blackbeard, Whitebeard (former)
Known to be the strongest Paramecia type of Devil Fruit, the Gura Gura no Mi allows the user to produce vibrations. As such, these vibrations can be channeled through the ground, the air, or any other medium, making the user of vibration man.
This Devil Fruit is used to create powerful quakes or even set off tsunamis. It is so dangerous that it is known to hold the power to destroy the entire world, which is something that can actually be held comparable to the Ancient Weapons themselves. Quite easily, one can see why this Devil Fruit can kill anyone in one shot.
Ryu Ryu no Mi, Model: Nidhoggr
- Type: Zoan
- User: Loki
The Ryu Ryu no Mi, Model: Nidhoggr, is a powerful Mythical Zoan Devil Fruit that is wielded by the Accursed Prince of Elbaf, Loki. This Devil Fruit is considered to be legendary and was passed down the royal family line in Elbaf for generations, until 14 years ago, when Loki ate it.
The powers of this Devil Fruit are such that it allows Loki to transform into the largest dragon in the world, called Nidhoggr, which is able to produce lightning. The lightning powers it offers can allow the user to destroy the whole world. With abilities such as Thorheim, the user can essentially kill practically anyone in one shot, and with repeated usage, even countries can be utterly destroyed.
Akuma no Mi
- Type: Unknown
- User: Nerona Imu
Introduced officially in One Piece Chapter 1179, the Akuma no Mi is a unique Devil Fruit. With no known classification, this Devil Fruit is among the strongest in the entire world, as it allows its user, Nerona Imu, to transform into the Devil God of the One Piece world.
Utilizing powers such as Demonic Contracts, it can turn anyone into demonic slaves, and it also allows the manipulation of a unique ability known as Omen or Maki. The firepower of this Omen is such that the vast majority can die in a single hit, and its powers simply cannot be matched.
One Piece is available to read via Manga Plus and Viz Media.