Scotrail has suspended all trains that run through the low level platforms at Glasgow Central due to a signalling fault.
Services that connect Dunbartonshire to Lanarkshire via Glasgow - running from Dalmuir through to Whifflet or Motherwell and from Milngavie or Dalmuir to Motherwell or Cumbernauld - are affected.
The signalling fault problem has occurred between Rutherglen and Anderston on the line.
Trains that uses the high-level platforms at Glasgow Central have not been affected by the disruption.
Among the stations affected is Exhibition Centre, which will be one of the main stations in use for the Commonwealth Games, as it serves the OVO Hydro and SEC Campus that will host a number of sports.
Although the games have not yet begun, athletes and team members from several competing nations can already be seen wandering about the area.
In a statement on social media, ScotRail wrote: "We're unable to run any trains via Glasgow Central Low Level and all trains out on this line will be recovered back to depots where possible.
"Services via Glasgow Central High Level and Queen Street Low Level are not affected at this time."
The rail operator added that Network Rail staff are currently at Anderston looking into the problem.
Network Rail said it was continuing to work to identify the cause of the fault with its signalling and power distribution teams.
Bus operator Whitelaws will accept train tickets on buses that run between Motherwell and Larkhall via Hamilton.