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Two different sections of the A14 have been shut because of separate serious incidents.
All lanes of the westbound carriageway have been closed between Rothwell and Kelmarsh in Northamptonshire after a van fire led to a large diesel spillage.
Crews were then called to a multi-vehicle collision and fire about 40 miles (64km) away near Bar Hill, Cambridgeshire, at about 19:30 BST. This also affected the westbound carriageway.
National Highways said emergency workers were at the scene of both incidents.
Diversions have been in place for motorists using the Northamptonshire stretch of road while junctions two and three are shut.
In Cambridgeshire, three out of the four lanes were closed between Bar Hill and Girton, where the A14 meets the M11.
National Highways said there were "no significant delays" in the area as of 20:00.
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